Article ID Journal Published Year Pages File Type
20309 Journal of Bioscience and Bioengineering 2015 5 Pages PDF
Abstract

Biologically active piperitone-derived racemic iodo-, bromo- and chlorolactones (1–3) were transformed with the use of microbial enzymatic systems. Four strains of filamentous fungi Absidia glauca AM254, Absidia cylindrospora AM336, Mortierella vinaceae AM149 and Nigrospora oryzae AM8 transformed halolactones (1–3) to four new halohydroxylactones (4–7). In all biotransformations the hydroxy group was incorporated in inactivated methine carbon atom at isopropyl substituent. In N. oryzae AM8 culture the bromolactone with additional hydroxy group in α-position, relative to CO bond in γ-lactone ring, was also formed as a product. The structures of new compounds were established on the basis of spectral data.

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