| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2031148 | Trends in Biochemical Sciences | 2010 | 10 Pages |
Abstract
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
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Authors
Lluís Morey, Kristian Helin,