| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2031505 | Trends in Biochemical Sciences | 2006 | 7 Pages |
Abstract
Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process.
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Authors
Xinxian Deng, Victoria H. Meller,