| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2031749 | Trends in Biochemical Sciences | 2008 | 4 Pages |
Abstract
Overexpression of steroid receptor coactivator 3 (SRC-3) is associated with an increased incidence of breast cancer. A recent study shows that SRC-3 is protected from proteasomal degradation by atypical protein kinase C (aPKC)-mediated phosphorylation in an estrogen receptor α (ERα)-dependent manner. This finding provides a novel mechanism for coupling increased SRC-3 expression with enhanced estrogen-dependent cellular proliferation.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Michael J. Garabedian, Susan K. Logan,