| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2031759 | Trends in Biochemical Sciences | 2008 | 4 Pages |
Abstract
PHD fingers and bromodomains are found in close proximity to each other in many chromatin-associated proteins and can functionally synergize. Recently, it has been demonstrated that the PHD finger of the KAP1 co-repressor functions as an E3 SUMO ligase for the adjacent bromodomain. This PHD-mediated SUMOylation stabilizes the association of the bromodomain with the chromatin modifiers SETDB1 and the nucleosome remodeling and deacetylation (NuRD) complex, thereby promoting establishment of the silent gene expression state.
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Authors
Jamy Peng, Joanna Wysocka,