Article ID Journal Published Year Pages File Type
20327 Journal of Bioscience and Bioengineering 2015 4 Pages PDF
Abstract

This investigation used in vivo and in vitro tools to study pharmacokinetics and glycosylation of two monomeric antibodies produced either transiently by HEK293 cells or stably by Chinese hamster ovary cells, and demonstrated that higher in vivo clearance of human embryonic kidney antibody was due to higher glycosylation, thus higher mannose receptor mediated uptake.

Related Topics
Physical Sciences and Engineering Chemical Engineering Bioengineering
Authors
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