| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2079389 | Computational and Structural Biotechnology Journal | 2012 | 11 Pages |
Abstract
In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Michael Widmann, Jürgen Pleiss, Anne K. Samland,