| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 21233 | Journal of Bioscience and Bioengineering | 2010 | 4 Pages |
Abstract
Aspergillus oryzae penicillin biosynthetic genes were clustered. The penicillin production was positively regulated by VeA, a global gene regulator required for transcriptional expression of the penicillin biosynthetic genes. Overexpression of the biosynthetic genes by a strong promoter yielded a greater than 100-fold increase in penicillin production.
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Authors
Junichiro Marui, Sumiko Ohashi-Kunihiro, Tomohiro Ando, Marie Nishimura, Hideaki Koike, Masayuki Machida,