| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 21514 | Journal of Bioscience and Bioengineering | 2010 | 4 Pages |
Abstract
HRAP, a pentapeptide designed to bind with the pertuzumab interacting site in an extracellular domain of the HER2 molecule, enhanced the cytotoxicity of paclitaxel in HER2-overexpressing human breast cancer cell lines, BT474 and SKBR-3, but not in MDA-231 cells, which express lower levels of HER2. HRAP enhanced mitochondria-dependent apoptosis induced by paclitaxel in SKBR-3 and BT-474, but not in MDA-231. HRAP enhanced the inhibition of phosphorylation of serine 473 in Akt and Ser380/Thy382/The383 in PTEN. These results suggest that HRAP enhances paclitaxel-induced apoptosis in a manner dependent on the PTEN/Akt signal transduction pathway.
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Authors
Hiroo Nakajima, Naruhiko Mizuta, Koichi Sakaguchi, Ikuya Fujiwara, Atsushi Yoshimori, Junji Magae, Sei-ichi Tanuma,