| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 21642 | Journal of Bioscience and Bioengineering | 2010 | 4 Pages |
Abstract
We engineered Lactobacillus paracasei to produce a dsRNA that would trigger RNAi-induced silencing of an essential gene in the nematode Caenorhabditis elegans. The dsRNA-expressing L. paracasei can be used in experiments conducted on culture plates and may also be used as an orally administrable dsRNA carrier for humans and other mammals.
Related Topics
Physical Sciences and Engineering
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Bioengineering
Authors
Ai Kuwahara, Masashi Arita, Akira Kushiro, Yasuji Sakube, Masahiko Sisido, Takashi Ohtsuki,