Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2188 | Acta Biomaterialia | 2006 | 6 Pages |
Abstract
Many calcium phosphate bone substitutes are based on the use of α-tricalcium phosphate (α-TCP) powder. This compound has been intensively studied, but some aspects of α-TCP reactivity are still controversial. The goal of this study was to determine the setting kinetics of α-TCP based on a new approach that compared particle size distribution data to isothermal calorimetry data. Results indicated that α-TCP conversion is mostly controlled by surface reactions, with at later stages a diffusion-controlled mechanism. The presence of an X-ray amorphous α-TCP fraction in the crystalline α-TCP powder increased the dissolution rate threefold, without modifying the reaction mechanism.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Marc Bohner, Anna K. Malsy, Christopher L. Camiré, Uwe Gbureck,