Induction of apoptotic cell death preferentially in reactive astrocytes by concanavalin A

When central nervous system is injured, reactive astrocytes form glial scar which prevents neuronal regeneration. We examined the effects of concanavalin A (ConA) in primary astrocytes, and found preferential apoptotic effect of ConA in migrating reactive astrocytes. Thus, ConA may be applicable for enhancing neuronal regeneration by preventing glial scar.