| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2199605 | Molecular and Cellular Probes | 2014 | 5 Pages |
Abstract
•Effect of light transition metal complexes of methanesulfonic acid hydrazide.•Cytostatic and cytotoxic effect of MSH and its transition metal complexes.•Tracing the changes in the cell morphology.
The effect of methanesulfonic acid hydrazide (MSH) and its complexes [M(MSH)4Cl2] (M = Mn, Fe, Co, Ni) and [Zn(MSH)2Cl2] on culture growth suppression and viability (Colony Forming Units) of Saccharomyces cerevisiae has been studied. The highest culture growth suppression was exhibited by [Co(MSH)4Cl2], whereas the most cytotoxic appeared [Mn(MSH)4Cl2]. The changes in cell morphology were also traced by means of FACS analysis.
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Authors
George A. Miloshev, Ekaterina N. Peycheva, Nicolay I. Dodoff, Daniel N. Kushev, Maria Lalia-Kantouri,