| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 22129 | Journal of Bioscience and Bioengineering | 2007 | 4 Pages |
Abstract
The potential involvement of the extracellular signal-regulated kinase (ERK) pathway in chondrocyte mechanotransduction was tested in bovine chondrocyte-agarose constructs under hydrostatic loading. Results suggested that the ERK pathway may be inhibited by hydrostatic pressure-induced mechanotransduction and may also be a negative regulator of Sox9 mRNA expression, which is an important modulator of chondrocyte function.
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Authors
Kensuke Mio, Jennifer Kirkham, William A. Bonass,