Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
22234 | Journal of Bioscience and Bioengineering | 2006 | 4 Pages |
Abstract
In order to study the feasibility of commercial-scale L-lactic acid production by Rhizopus sp. MK-96-1196 using large scale airlift bioreactors (ALBs), a scale-up study from 0.003 m3 to 5 m3 ALB was carried out using oxygen transfer rate (OTR) as the scale-up criterion. Enhanced L-lactic acid production was achieved at OTRs higher than 0.28 (g-O2/l/h) irrespective of the scale of the bioreactor in question: in the range of 0.003 m3 to 5 m3, more than 90 g/lL-lactic acid was produced with a yield of approximately 80%, based on the initial glucose concentration. In future research, we plan to design an ALB greater than 3000 m3 (working volume: 2000 m3) for further studies on the production of L-lactic acid in large quantities.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Tiejun Liu, Shigenobu Miura, Masaaki Yaguchi, Tomohiro Arimura, Enock Y. Park, Mitsuyasu Okabe,