Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
23484 | Journal of Biotechnology | 2013 | 5 Pages |
Abstract
Four halogenated cyclopropane derivatives with a side chain containing a primary (1 and 2) or secondary (3 and 4) alcohol moiety were subject to kinetic resolution catalyzed by lipases. Two of them containing secondary alcohol groups gave excellent results with Candida antarctica lipase B with E-values around 1000. Two enantiopure alcohols and two enantiopure butanoates are described: (1S,1′S)-1-(2′,2′-dichloro-3′,3′-dimethylcyclopropyl) ethanol (3), the corresponding (1R,1′R)-butanoate (3b) and (1S,1′S)-1-(1′-methyl-2′,2′-dibromocyclopropyl) ethanol (4) and the corresponding (1R,1′R)-butanoate (4b).
Keywords
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Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Elisabeth Egholm Jacobsen, Mohammed Farrag el-Behairy, Lars Skattebøl, Thorleif Anthonsen,