Article ID Journal Published Year Pages File Type
240039 Procedia Chemistry 2014 8 Pages PDF
Abstract

Micronization of fenofibrate using top-down process via jet mill and bottom-up process via rapid expansion of supercritical solution (RESS) was conducted to investigate their effects on the formation of micronized fenofibrate. Processed fenofibrate retained its crystalline structure and have similar chemical structure with unprocessed fenofibrate. The average particle size of fenofibrate was reduced from its original wherein from 68.779±0.146 μm to 3.050±0.085 μm using jet mill process at SFR 2.7 kg/h; and to 3.044±0.056 μm using RESS under the optimum condition. The results revealed that jet mill and RESS processes were applicable for micronization of fenofibrate.

Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)