Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2400484 | Medical Mycology Case Reports | 2016 | 4 Pages |
•Azole resistance acquisition by Candida tropicalis is reported.•Studied isolates came from a dog with persistent urinary candidiasis.•Pre- and post-antifungal treatment isolates were clonally related.•A novel frameshift mutation in the ERG3 gene was found in post-treatment isolates.
Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene, but the latter displayed increased azole minimum inhibitory concentrations. A novel frameshift mutation in ERG3 was found in some isolates recovered after resistance development, so it appears unlikely that this mutation is responsible for multi-azole resistance.