Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2401406 | Tuberculosis | 2013 | 6 Pages |
Abstract
SummaryMicroRNAs (miRNAs) have been demonstrated to play a pivotal role in the regulation of target gene expression at the post-transcriptional level. In order to better understand the role of miRNA in the immunological regulation of macrophages against Mycobacterium bovis BCG infection, we explored the alteration of immune-related miRNA profile in macrophage RAW264.7 cells in response to BCG infection in this study. Our results demonstrated that miR-142-3p was a potential to negatively regulate the production of pro-inflammatory mediators NF-κB (NF-κB1), TNF-α and IL-6 in the macrophages in part through a mechanism of targeting IRAK-1 gene and post-transcriptionally down-regulating IRAK-1 protein expression.
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Authors
Guangxian Xu, Zhaobo Zhang, Jun Wei, Yilin Zhang, Ying Zhang, Le Guo, Xiaoming Liu,