Clarithromycin

Generic and additional names: ClarithromycinCAS name: 6-O-MethylerythromycinCAS registry #: 81103-11-9Molecular formula: C38H69NO13Molecular weight: 747.95Intellectual property rights: GenericBrand names: Biaxin (Abbott); Clathromycin (Taisho); Cyllind (Abbott); Klacid (Abbott); Klaricid (Abbott); Macladin (Guidotti); Naxy (Sanofi Winthrop); Veclam (Zambon); Zeclar (Abbott)Solubility: Clarithromycin is soluble in acetone, slightly soluble in methanol, ethanol, and acetonitrile, and practically insoluble in water [FDA label]. Water solubility 0.33 mg/l [DrugBank].Polarity: Log P 2.69 [DrugBank]. Other authors have obtained values of Log P = 1.7 at pH 7.4.1Acidity/basicity: pKa 8.99 [DrugBank]Melting point: 217–220ºC [DrugBank]Formulation and optimal human dosage: Biaxin is available as immediate-release tablets, extended-release tablets, and granules for oral suspension.Each Biaxin tablet contains 250 mg or 500 mg of clarithromycin.After constitution, each 5 ml of Biaxin suspension contains 125 mg or 250 mg of clarithromycin. Dose 250–1000 mg daily, higher amounts given in multiple doses [FDA label].Figure optionsDownload full-size imageDownload high-quality image (39 K)Download as PowerPoint slide