Ethambutol

Generic and additional names: Ethambutol; (+)-2,2′-(ethylenediimino)di-1-butanol; d-N,N′-bis(1-hydroxymethylpropyl)ethylenediamine; EMBCAS name: 2, 2′-(1,2-Ethanediyldiimino)bis-1-butanolCAS registry #: 74-55-5Molecular formula: C10H24N2O2Molecular weight: 204.31Intellectual property rights: Generic, first used in TB treatment in 1966Brand names: Aethambutolum, D-Ethambutol, Dadibutol, Diambutol, EMB, Ethambutol HCL, Etibi, Myambutol, TibutolSolubility: Dihydrochloride: Soluble in water, DMSO; sparingly soluble in ethanol; difficult to dissolve in acetone and chloroform [Merck Index]Polarity: Log P −0.14 [DrugBank]Acidity/basicity: ETH HCl has two apparent dissociation constants, pKa1 = 6.35, pKa2 = 9.35. In solution at neutrality the monohydrochloride predominates1Melting point: ETH, 88ºC; ETH HCl, 200ºC [Merck Index]Formulation and optimal human dosage: Available as 100 and 400 mg tablets. 15 mg/kg daily or up to 25 mg/kg but risk of ocular toxicity. Weekly dose, 30 mg/kg 3 times/week [FDA label].Figure optionsDownload full-size imageDownload high-quality image (10 K)Download as PowerPoint slide