Linezolid

Generic and additional names: LinezolidCAS name: N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamideCAS registry #: 165800-03-3Molecular formula: C16H20FN3O4Molecular weight: 337.35Intellectual property rights: PfizerBrand names: Zyvox, Zyvoxid (Pfizer)Derivatives: Dong-A Pharmaceutical has reported several new oxazolidinones (DA-7157, DA-7218 and DA-7867) having somewhat improved in-vitro potency, compared to linezolid, against Mycobacterium tuberculosis, M. kansasii and M. marinum1,2Solubility: In water up to 3 mg/ml [DrugBank]Polarity: Log P 0.232 [DrugBank]Melting point: 181.5 182.5ºC [Merck Index]Formulation and optimal human dosage: Zyvox tablets for oral administration contain 400 mg or 600 mg linezolid.Zyvox i.v. injection is supplied as a 2 mg/ml isotonic solution for intravenous infusion.Doses: oral or i.v. 600 mg every 12 hours for serious infections and 400 mg every 12 hours for uncomplicated infection [FDA label].Figure optionsDownload full-size imageDownload high-quality image ( K)Download as PowerPoint slide