Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2402138 | Tuberculosis | 2006 | 5 Pages |
Abstract
SummaryThe effect of the administration of a commercial preparation of human gamma globulins has been evaluated in a mouse model of intranasal infection with BCG. First, we demonstrated the passage of specific antibodies to saliva and lung lavage following the intranasal or intraperitoneal administration to mice of human gamma globulins. This treatment of mice inhibited BCG colonization of the lungs (p<0.01)(p<0.01). A similar inhibitory effect was observed after infection of mice with gamma globulin opsonized BCG organisms (p<0.01)(p<0.01). These results are relevant for the development of new strategies for the control and treatment of tuberculosis.
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
Nesty Olivares, Annette León, Yamilé López, Alina Puig, Armando Cádiz, Gustavo Falero, Máximo Martínez, Maria E. Sarmiento, Mildrey Fariñas, Juan F. Infante, Gustavo Sierra, Rosa L. Solís, Armando Acosta,