Article ID Journal Published Year Pages File Type
24478 Journal of Biotechnology 2010 4 Pages PDF
Abstract

Nitroalkanes underwent fast additions to a variety of structurally diverse aldehydes under the catalysis of d-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen products were obtained in short time with moderate to high yields. It is the first report on hydrolase-catalyzed fast Henry reaction in organic solvent.

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Physical Sciences and Engineering Chemical Engineering Bioengineering
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