Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
24549 | Journal of Biotechnology | 2009 | 4 Pages |
Abstract
Among the five vinyl esters bearing phenyl ring in acyl moiety, the lipase from Burkholderia cepacia was most specific toward vinyl 4-phenylbutyrate. Additionally, 3′-regioselectivity of the enzyme was enhanced with the increment of acyl chain length. The lipophilic 3′-arylaliphatic acid esters of floxuridine, its potential prodrugs, were synthesized with high conversions (>98%) and good to excellent regioselectivities (85–99%) via the enzymatic approach.
Related Topics
Physical Sciences and Engineering
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Authors
Ning Li, Quan-Ming Zeng, Min-Hua Zong,