Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.

Graphical abstractExosomes are small vesicles secreted by various cell types and are involved in many biological functions. There is also significant evidence on critical role played by exosomes in many diseases. Here we discuss regarding their potential usage and relevance in therapeutic drug delivery.Figure optionsDownload full-size imageDownload as PowerPoint slide