| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2474605 | Acta Pharmaceutica Sinica B | 2015 | 7 Pages |
The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, and non-coding RNAs. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation. The epigenetic mechanisms have important clinical implications and may provide insights into effective drug development and improve safety of drug therapy.
Graphical abstractThe drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug metabolizing enzyme genes has emerged as an important mechanism. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation.Figure optionsDownload full-size imageDownload as PowerPoint slide
