Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2474715 | Acta Pharmaceutica Sinica B | 2012 | 8 Pages |
Abstract
Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC–MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and lending clues to mechanisms of bioactivation. Thus, the LC–MS-based metabolomic approach is a powerful tool for profiling of drug metabolism and bioactivation.
Graphical abstractThe LC–MS-based metabolomic approach is a powerful, effective and unbiased tool for profiling of drug metabolism and bioactivation. Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Feng Li, Frank J. Gonzalez, Xiaochao Ma,