Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2474750 | Acta Pharmaceutica Sinica B | 2015 | 5 Pages |
A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo Kα radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC50 values of 7.7, 7.0, and 16.5 nmol/L, respectively.
Graphical abstractA bicyclic depsipeptide, chromopeptide A, was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC50 values of 7.7, 7.0 and 16.5 nmol/L, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide