| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2474758 | Acta Pharmaceutica Sinica B | 2011 | 4 Pages |
Abstract
Aminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis. Peptides containing the Asn-Gly-Arg (NGR) motif can specifically recognize APN/CD13 allowing them to act as tumor-homing peptides for the targeted delivery of anti-tumor drugs to tumor neovascular endothelial cells and tumor cells. This article reviews the literature and recent developments related to APN/CD13, its role in tumor growth and some anti-tumor drug delivery systems containing NGR peptides designed to target APN/CD13.
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Authors
Xun Wang, Bin Wang, Qiang Zhang,