| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2474760 | Acta Pharmaceutica Sinica B | 2011 | 4 Pages |
Two new ar-bisabol sequiterpenes, (+)-(7S,10S)-10-epi-7,10-epoxy-3-hydroxy-ar-bisabol-11-ol (1) and (+)-(7R,8R,10S)-10-epi-7,10-epoxy-8-hydroxy-ar-bisabol-11-ol (2), have been isolated by a combination of various column chromatographic techniques including reversed-phase semipreparative HPLC from an ethanol extract of the stem bark of Fraxinus sielboldiana. Their structures were determined by spectroscopic methods including IR, MS, and 1D and 2D NMR experiments. This is the first report of sequiterpenes in the genus Fraxinus.
Graphical abstractTwo new ar-bisabol sequiterpenes, (+)-(7S,10S)-10-epi-7,10-epoxy-3-hydroxy-ar-bisabol-11-ol (1) and (+)-(7R,8R,10S)-10-epi-7,10-epoxy-8-hydroxy-ar-bisabol-11-ol (2), have been isolated and determined for the first time.Figure optionsDownload full-size imageDownload as PowerPoint slide
