Fundamental aspects of solid dispersion technology for poorly soluble drugs

The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system, the drug–polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology.

Graphical abstractA solid dispersion is basically a drug–polymer two-component system in which the mechanism of drug dispersion is the key to understanding its behavior. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution emphasizing the fundamental aspects of this important technology.Figure optionsDownload full-size imageDownload as PowerPoint slide