Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2474826 | Acta Pharmaceutica Sinica B | 2011 | 4 Pages |
From a further purification study, two new congeners designated cyslabdans B (1) and C (2) were isolated along with previously reported cyslabdan (cyslabdan A (3) in this study) from the culture broth of Streptomyces sp. K04-0144. The structure was elucidated by various spectroscopy including NMR, revealing that 1 and 2 was 18-hydroxy and 1′-methoxy cyslabdan, respectively. Compounds 1 and 2 were found to potentiate imipenem activity against methicillin-resistant Staphylococcus aureus by 123 fold and 533 fold, respectively. Comparison with the activity of compound 3 indicated that the introduction of a hydrophilic group at the dimethyl moiety of the decalin ring was unfavorable for its activity.
Graphical AbstractTwo new congeners designated cyslabdans B (1) and C (2) were isolated from the culture broth of Streptomyces sp. K04-0144, which were found to potentiate imipenem activity against methicillin-resistant Staphylococcus aureus by 123 fold and 533 fold, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide