A new megastigmane from fresh roots of Rehmannia glutinosa

A new megastigmane, rehmamegastigmane (1), together with eighteen known compounds lariciresinol (2), lariciresinol-4′-O-β-d-glucopyranoside (3), hierochin D (4), yemuoside YM1 (5), darendoside B (6), decaffeoylacteoside (7), jionoside B1 (8), catalpol (9), ajugol (10), 6-O-vanilloylajugol (11), 6-O-E-feruloylajugol (12), rehmapicroside (13), rehmapicrogenin (14), 3-methoxy-2,6,6-trimethylcyclohexane-1-enecarboxylic acid (15), vanillic acid (16), hydroferulic acid (17), threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol (18), p-hydroxyphenylethyl alcohol (19) was isolated from the fresh roots of Rehmannia glutinosa. Compounds 2–6 and 16–18 were isolated from this plant for the first time.

Graphical abstractA new megastigmane, rehmamegastigmane, together with eighteen known compounds was isolated from the fresh roots of Rehmannia glutinosa.Figure optionsDownload full-size imageDownload as PowerPoint slide