| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2478648 | Bulletin of Faculty of Pharmacy, Cairo University | 2015 | 8 Pages |
Abstract
The synthesis of some new 3,4-disubstituted thiazolylideneisonicotinohydrazide derivatives 3a–k, 2-substituted thiazolidinylisonicotinamide derivatives 4a–d and pyrrolylisonicotinamide derivatives 5, 6 and 7 is described. The resulted compounds are evaluated for their in vitro antitubercular activity. The minimum inhibitory concentration (MIC) of compound 3g showed comparable in vitro activity to isoniazid against Mycobacterium tuberculosis H37Ra 7131 strain in concentration 9.77 μg/mL.
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Authors
Maha A. Elhakeem, Azza T. Taher, Suzan M. Abuel-Maaty,