Article ID Journal Published Year Pages File Type
2479 Acta Biomaterialia 2007 9 Pages PDF
Abstract

Self-setting biomaterials are widely used for tissue repair and regeneration. Calcium sulfate hemihydrate has been used for many years as a self-setting biomaterial due to its good setting properties. However, too fast a degradation rate and lack of bioactivity have limited its application in orthopaedic field. Herein, tricalcium silicate was introduced into calcium sulfate hemihydrate (CaSO4 · 1/2H2O) to form a calcium sulfate hemihydrate-based composite, and its behavior as a cement was studied in comparison with pure calcium sulfate hemihydrate. The results indicated that the workability and setting time of the composite pastes are higher than those of pure CaSO4 · 1/2H2O, and the composite pastes showed much better short- and long-term mechanical properties than those of pure CaSO4 · 1/2H2O. Moreover, the biphasic specimens showed significantly improved bioactivity and degradability compared with those of pure CaSO4 · 1/2H2O, indicating that the composite cements might have a significant clinical advantage over the traditional CaSO4 · 1/2H2O cement.

Related Topics
Physical Sciences and Engineering Chemical Engineering Bioengineering
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