| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2480155 | European Journal of Pharmaceutical Sciences | 2016 | 6 Pages |
Abstract
A series of related thalidomide derivatives (2–9) were synthesized by microwave irradiation and evaluated for anti-inflammatory activity. Such activity was assessed in vivo and ex vivo. Compounds 2, 8 and 9 showed the highest levels of inhibition of TNF-α production. On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity. Thus, compound 9 can be considered as a promising compound to be subjected to further modification to obtain new agents for the treatment of inflammatory diseases.
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Authors
Juan José Casal, Mariela Bollini, María Elisa Lombardo, Ana María Bruno,