| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2482179 | European Journal of Pharmaceutical Sciences | 2009 | 6 Pages |
Abstract
Three crystalline hemi-hydrate, channel solvates (classified as solvates from here on) of finasteride (N-(1,1-di-methylethyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide) have been obtained and fully characterized. The acetone, methyl ethyl ketone (MEK), and toluene solvates of finasteride, described herein, were found to be isostructural and belong as additional members to a family of previously reported finasteride solvates. Vacuum drying at 85 °C for 1 day produced the metastable, anhydrous Form II of finasteride from all three solvated materials.
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Authors
Nate Schultheiss, Jared P. Smit, Jason A. Hanko,