Article ID Journal Published Year Pages File Type
2483160 Journal of Drug Delivery Science and Technology 2015 4 Pages PDF
Abstract

The delivery of antibiotics to the lungs provides a straightforward treatment for lung infections. In this study, the antibiotic of aztreonam (AZT) was spray-dried to prepare drug particles for inhalation. Unlike traditional spray-dried formulations, in which excipients are used to improve powder dispersibility, in this study no excipients were added. Importantly, the excipient-free, AZT spray-dried powders showed excellent flowability, dispersibility and aerosolisation performance. A large amount of drug particles was delivered to the lower stages in the in-vitro aerosolisation test, and the fine particle fraction (particle size < 4.46 μm) was as high as 45% w/w, suggesting an effective delivery of drug particles to the lungs. These excipient-free, AZT spray-dried powders, thus, show an interesting potential to be used as inhaled drugs for the effective treatment of lung infections.

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Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery
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