Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2483359 | Journal of Drug Delivery Science and Technology | 2014 | 5 Pages |
Abstract
Solubilities of three drugs, i.e. atenolol, amiodarone HCl and lamotrigine in binary mixtures of polyethylene glycol 200 + water in the presence of beta-cyclodextrin (β-CD) along with the solubilities of atenolol and amiodarone HCl in this solvent mixture in the absence of β-CD using saturating shake flask method were studied. The generated solubility data was fitted to the Jouyban-Acree model and the solubility profile of each drug in the presence of β-CD was compared with solubility data in the absence of β-CD that the solubility data of lamotrigine taken from a previous paper.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery