| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2483661 | Journal of Drug Delivery Science and Technology | 2010 | 7 Pages |
The purpose of this study was to evaluate the usefulness of a new disintegration testing apparatus, ODT-101, and to investigate the effects of the physical properties of orally disintegrating tablets (ODTs) on their disintegration time. We prepared ODTs of different weights and diameters at different tabletting pressures using an excipient Ludiflash. Disintegration times were measured by human sensory evaluation and using the ODT-101. The disintegration time measured by the ODT-101 was found to be in good agreement with that measured in the oral cavity. Disintegration time was found to be a function of porosity and weight, regardless of ODT shape, and to be an exponential function of the hardness of the ODT. In conclusion, ODT-101 testing is accurate enough to be a substitute for sensory evaluation and the hardness of the ODT is a good marker for disintegration time.
