| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2483821 | Journal of Drug Delivery Science and Technology | 2007 | 6 Pages |
To prevent the drug release and degradation in gastric medium, naringin and naringenin gastro-resistant microparticles were formulated. (CAP) as coating material and spray-drying technique were tested to obtain a controlled drug release to the intestine. The influence of parameters such as the composition of the feed solution and polymer concentration on the particle yield, behavior and morphology was investigated. The microparticles were characterized by scanning electron microscopy (SEM), fluorescence microscopy (FM), and differential scanning calorimetry (DSC). In vitro dissolution studies, carried out using a pH change method, revealed that gastro-resistant naringin- and naringenin-loaded microparticles are obtainable from 2% buffer aqueous feed solutions in different polymer/drug ratios (1:1, 3:1, 5:1) by spray-drying. The method appears to be an efficient means of stabilizing these labile drugs and of obtaining a biphasic release trend due to the adequate coating properties and to the pH dependent solubility of the polymer.
