| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2483939 | Journal of Drug Delivery Science and Technology | 2007 | 5 Pages |
Abstract
Similarities between a unicellular eukaryotic organism Tetrahymena and human cells as well as the ease in management of Tetrahymena cultures stimulated us to investigate this organism as a model for a rapid in vitro test for drugs from the NSAIDs family that could allow for a cellular assay to predict drug blood therapeutic levels. For this purpose, we quantified, by image analysis, changes in Tetrahymena thermophila (TT) cell area as a function of NSAID concentration, and found a correlation with drug effective plasma levels in humans.
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