Application of electro-hydro-dynamic atomization in drug delivery

The presented paper is a review on electro-hydro-dynamic atomization (electrospray) applied in the production of drug eluting particles and fibers. In the first part EHDA technology is briefly described including all the practical aspects concerning process stability, reactor design, prediction of droplet size, particle drying process and particle collection as well as different derivatives of EHDA technique as applied in drug delivery and drug microencapsulation. Also a novel vertical type of reactor for particle production by EHDA is presented. In the second part particular applications of EHDA in drug encapsulation and delivery which are published in the literature are described and characterized.