| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2484494 | Journal of Pharmaceutical Sciences | 2016 | 7 Pages |
Abstract
A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I > group III > group II.
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Authors
Inese SarceviÄa, Ilze Grante, Sergey Belyakov, Toms Rekis, KÄrlis BÄrziÅÅ¡, Andris ActiÅÅ¡, LiÄna Orola,