Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2484600 | Journal of Pharmaceutical Sciences | 2015 | 11 Pages |
Abstract
The aim of this study was to investigate the role of porosity on the compression behavior and tablet tensile strength for granules produced by a dry granulation procedure. Microcrystalline cellulose was used as a typical pharmaceutical excipient and a comparison was made with the effect of granule porosity on the compression behavior and tablet tensile strength of wet-processed granules of the same composition. Both the wet and dry granulation process caused a loss in compactibility of the material that was controlled by the granule porosity up to a critical point of porosity and friability. Above this threshold value of porosity, the granules nearly collapsed completely into primary particles during compression. In these cases, the micro-structure and tensile strength of the formed tablets resembled that of tablets formed from the original ungranulated powder.
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Josefina Nordström, Göran Alderborn,