Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2484627 | Journal of Pharmaceutical Sciences | 2015 | 8 Pages |
Abstract
Clopidogrel hydrogensulfate (HSCL) is an antiplatelet agent, one of top-selling drugs in the world. In this paper, we have described a rapid and convenient method of verification which polymorph of HSCL is present in its final solid dosage form. Our methodology based on solid-state NMR spectroscopy and ab initio gauge-including projector-augmented wave calculations of NMR shielding constants is appropriate for currently available commercial solid dosage forms of HSCL. Furthermore, such structural characterization can assist with the development of new pharmaceutical products containing HSCL and also be useful in the identification of counterfeit drugs. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:106-113, 2015
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Edyta Pindelska, Lukasz Szeleszczuk, Dariusz Maciej Pisklak, Andrzej Mazurek, Waclaw Kolodziejski,