Article ID Journal Published Year Pages File Type
2484815 Journal of Pharmaceutical Sciences 2013 11 Pages PDF
Abstract

ABSTRACTBuilding upon many classical foundations of pharmacology, a diverse array of mechanistic pharmacokinetic-pharmacodynamic (PK/PD) models have emerged based on mechanisms of drug action and primary rate-limiting or turnover processes in physiology. An array of basic models can be extended to handle various complexities including tolerance and can readily be employed as building blocks in assembling enhanced PK/PD or small systems models. Our corticosteroid models demonstrate these concepts as well as elements of horizontal and vertical integration of molecular to whole-body processes. The potential advantages and challenges in moving PK/PD toward systems models are described.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery
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