| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2484926 | Journal of Pharmaceutical Sciences | 2010 | 7 Pages |
Abstract
The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated for particle size, encapsulation efficiency, swellability, and in vitro drug release. The size of the hydrogel was found to nanorange. The integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The CS-Ac-PAMAM hydrogel was developed based on the modulation of ratio show promise as a system for controlled delivery of drug.
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Authors
Mohammad Reza Saboktakin, Roya M. Tabatabaie, Abel Maharramov, Mohammad Ali Ramazanov,