Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485115 | Journal of Pharmaceutical Sciences | 2007 | 11 Pages |
Abstract
A novel formulation process via coâspray drying ibuprofen (IBU) with mesoporous SBAâ15 submicron particles exhibited excellence in production of stable amorphous IBU with significantly enhanced dissolution rate. With drug loading of IBU/SBAâ15 ratio being 50:50 (w/w) or below, most drug molecules were entrapped inside the straight mesoporous channels via the coâspray drying and the morphology of SBAâ15 submicron particles remained unchanged. IBU confined inside the mesoporous structure was in the amorphous state shown by PXRD and DSC measurements. The amorphous state of IBU in the solid dispersion showed remarkable stability when subject to stress test condition of 40°C/75% RH in open pans for 12 months. The uniform pore walls were believed to prevent the reâcrystallization of the homogeneously dispersed drug molecules inside the mesoporous channels with confined nanospace. The dissolution rate of IBU from the coâsprayâdried solid dispersion was significantly enhanced to achieve a rapid release. Even after the accelerated stability test, the rapid drug release property was well preserved. © 2009 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1997-2007, 2010
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Authors
ShouâCang Shen, Wai Kiong Ng, Leonard Chia, YuanâCai Dong, Reginald B.H. Tan,